Evolution and consequences of aneuploidy during tumorigenesis
(a) Experimental design of the teratoma assay. (b) Genome-wide plot of chromosome copy number alteration of teratomas grown from reversine-treated TP53–/– hESCs.
2
Establishment of sister-chromatid cohesion during DNA replication
(a) Architecture of the cohesin ring or MCM2-7 complex. (b) Cohesin dynamics during the cell cycle.
3
3D genome organization and cell fate decisions
(a) Cohesin-CTCF mediated loop extrusion model. (b) Structure of Cohesin-NIPBL-CTCF complex. (c)characterization of human cerebral organoids.
