研究方向

1

基因组不稳定性与肿瘤发生机制

(a) Experimental design of the teratoma assay. (b) Genome-wide plot of chromosome copy number alteration of teratomas grown from reversine-treated TP53–/– hESCs.

2

利用人脑类器官研究人脑的发育及神经退行性疾病

(a) Architecture of the cohesin ring or MCM2-7 complex. (b) Cohesin dynamics during the cell cycle.

3

三维基因组与细胞命运决定

(a) Cohesin-CTCF mediated loop extrusion model. (b) Structure of Cohesin-NIPBL-CTCF complex. (c)characterization of human cerebral organoids.